ECM-mimicking nanofibrous scaffold enriched with dual growth factor carrying nanoparticles for diabetic wound healing
نویسندگان
چکیده
منابع مشابه
Dual growth factor releasing multi-functional nanofibers for wound healing.
The objective of this research is to develop a dual growth factor-releasing nanoparticle-in-nanofiber system for wound healing applications. In order to mimic and promote the natural healing procedure, chitosan and poly(ethylene oxide) were electrospun into nanofibrous meshes as mimics of extracellular matrix. Vascular endothelial growth factor (VEGF) was loaded within nanofibers to promote ang...
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-Chitosan is natural polysaccharide resembles with glycosaminoglycan of Extra Cellular matrix (ECM), which makes it a promising candidate for wound healing application apart from its excellent biocompatibility and biodegradability. In this study we have formulated various types of chitosan gel by dissolving different concentrations of chitosan powder in 100 ml of 2% acetic acid separately. Elec...
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Diabetes mellitus is most common disease of the altered glucose homeostasis. Diabetics have impaired wound healing and impaired formation of coronary collaterals. The abnormal apoptosis or angiogenesis may cause many of the clinical manifestations of diabetes. Silver has been known to have effective bactericidal properties for centuries. Nowadays, silver-based topical dressings have been widely...
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ژورنال
عنوان ژورنال: Nanoscale Advances
سال: 2021
ISSN: 2516-0230
DOI: 10.1039/d0na00926a